Article

HB-EGF Signaling is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

2019-06-27

Abstract excerpt

<h4>ABSTRACT</h4> The molecular mechanisms of β-cell compensation to metabolic stress are poorly understood. We previously observed that nutrient-induced β-cell proliferation in rats is dependent on Epidermal Growth Factor Receptor (EGFR) signaling. The aim of this study was to determine the role of the EGFR ligand Heparin-Binding EGF-like Growth Factor (HB-EGF) in the β-cell proliferative response to glucose, a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 33992fce-f847-58fa-8ce1-8794cff82a26
DOI: 10.1101/683003

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HB-EGF Signaling is Required for Glucose-Induced Pancreatic β-Cell Proliferation in RatsDOI 10.1101/683003Read

Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases.Semantic proximity Read

GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor.Semantic proximity Read

Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets.Semantic proximity Read

Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loopSemantic proximity Read

Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.Semantic proximity Read

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a mediator of multiple physiological and pathological pathways.Semantic proximity Read

Glucolipotoxicity-induced Mig6 desensitizes EGFR signaling and promotes pancreatic beta cell deathSemantic proximity Read

Insulin and epidermal growth factor suppress basal glucose-6-phosphatase catalytic subunit gene transcription through overlapping but distinct mechanisms.Semantic proximity Read

Regulation of Insulin Gene Transcription by ERK1 and ERK2 in Pancreatic β CellsSemantic proximity Read

Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthoodSemantic proximity Read

EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathwaysSemantic proximity Read

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function.Semantic proximity Read