Article

Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood

2022-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Puberty is associated with transient insulin resistance that normally recedes at the end of puberty; however, in overweight children insulin resistance persists leading to an increased risk of type 2 diabetes. The mechanisms whereby pancreatic β cells adapt to pubertal insulin resistance, and how they are affected by the metabolic status, have not been investigated. Here we show that puberty is...

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Literature Corpus work: bb6a5eb4-ab59-5235-8fa5-d793867222bf
DOI: 10.1101/2022.04.06.487366

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