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Article

Insulin and epidermal growth factor suppress basal glucose-6-phosphatase catalytic subunit gene transcription through overlapping but distinct mechanisms.

The Biochemical journal - 15 Jan 2009

Onuma Hiroshi, Oeser James K, Nelson Bryce A, Wang Yingda, Flemming Brian P, Scheving Lawrence A, Russell William E, O'Brien Richard M

Abstract excerpt

The G6Pase (glucose-6-phosphatase catalytic subunit) catalyses the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate to glucose. We show here that, in HepG2 hepatoma cells, EGF (epidermal growth factor) inhibits basal mouse G6Pase fusion gene trans...

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Source

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Identifiers

PMID: 18847435
DOI: 10.1042/BJ20080999
PMCID: PMC2929524

Genes

EGF
FOXA2
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18847435-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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