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Article

The role of somatic mutational events in the pathogenesis of epilepsy

28 Feb 2019

Abstract excerpt

PURPOSE OF REVIEW: There has been rapid progress in defining novel causative gene variants responsible for a large spectrum of human epilepsy syndromes and subtypes. Of particular interest is the discovery that somatic mutations, for example, noninherited mutations occurring in neuroglial progenitor cells during embryonic brain development, are highly linked to malformations of cortical development (MCD) such as...

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PMID: 30762606
DOI: 10.1097/wco.0000000000000667

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