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Article

Transmembrane topology of mammalian planar cell polarity protein Vangl1.

Biochemistry - 29 Mar 2011

Iliescu Alexandra, Gravel Michel, Horth Cynthia, Apuzzo Sergio, Gros Philippe

Abstract excerpt

Vangl1 and Vangl2 are membrane proteins that play an important role in neurogenesis, and Vangl1/Vangl2 mutations cause neural tube defects in mice and humans. At the cellular level, Vangl proteins regulate the establishment of planar cell polarity (PCP), a process requiring membrane assembly of asymmetrically distributed multiprotein complexes that transmit polarity information to neighboring cells. The membrane...

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PMID: 21291170
DOI: 10.1021/bi101767a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Transmembrane topology of mammalian planar cell polarity protein Vangl1.PMID 21291170Read ↗

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