Article

Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway

2017-01-18

Abstract excerpt

In S. cerevisiae , the phosphate starvation (PHO) responsive transcription factors Pho4 and Pho2 are jointly required for induction of phosphate response genes and survival in phosphate starvation conditions. In the related human commensal and pathogen C. glabrata , Pho4 is required but Pho2 is dispensable for survival in phosphate-limited conditions and is only partially required for inducing the phosphate resp...

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Literature Corpus work: 3346f92a-0313-5d6d-b438-cdc6aa6e82d4
DOI: 10.1101/101154

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