Article
Novel acid phosphatase in Candida glabrata suggests selective pressure and niche specialization in the phosphate signal transduction pathway.
Genetics - 1 Nov 2010
Orkwis Brianne R, Davies Danielle L, Kerwin Christine L, Sanglard Dominique, Wykoff Dennis D
Abstract excerpt
Evolution through natural selection suggests unnecessary genes are lost. We observed that the yeast Candida glabrata lost the gene encoding a phosphate-repressible acid phosphatase (PHO5) present in many yeasts including Saccharomyces cerevisiae. However, C. glabrata still had phosphate starvation-inducible phosphatase activity. Screening a C. glabrata genomic library, we identified CgPMU2, a member of a...
Topics
- Acid Phosphatase
- Amino Acid Sequence
- Candida glabrata
- Enzyme Induction
- Evolution, Molecular
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Gene Library
- Genes, Fungal
- Genetic Complementation Test
- Hydrolysis
- Molecular Sequence Data
- Mutation