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Article

Novel acid phosphatase in Candida glabrata suggests selective pressure and niche specialization in the phosphate signal transduction pathway.

Genetics - 1 Nov 2010

Orkwis Brianne R, Davies Danielle L, Kerwin Christine L, Sanglard Dominique, Wykoff Dennis D

Abstract excerpt

Evolution through natural selection suggests unnecessary genes are lost. We observed that the yeast Candida glabrata lost the gene encoding a phosphate-repressible acid phosphatase (PHO5) present in many yeasts including Saccharomyces cerevisiae. However, C. glabrata still had phosphate starvation-inducible phosphatase activity. Screening a C. glabrata genomic library, we identified CgPMU2, a member of a...

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Identifiers

PMID: 20739710
DOI: 10.1534/genetics.110.120824
PMCID: PMC2975289

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