Patterning defects in mice with defective ventricular wall maturation and cardiomyopathy

Abstract excerpt

Ventricular chamber development involves the coordinated maturation of diverse cell populations. In the human fetal heart, single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics reveal marked regional gene expression differences. In contrast, the mouse ventricular wall appears more homogeneous, except for a transient hybrid cardiomyocyte population co-expressing compact ( Hey2 ) and trabecular ( Irx3...

Topics

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• 14-3-3 protein interactions
• Cardiac Structural Anomalies and Repair
• Cardiomyopathy and Myosin Studies
• Congenital heart defects research
• Connective tissue disorders research
• Pluripotent Stem Cells Research
• Protein Tyrosine Phosphatases
• Tissue Engineering and Regenerative Medicine

Identifiers and source

Literature Corpus work

992489b1-4534-52f7-8c49-efdd672d7800

DOI

10.1101/2025.05.22.655570