Article

Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data

2016-08-15

Abstract excerpt

Across many species, a large fraction of genetic variants that influence phenotypes of interest is located outside of protein-coding genes, yet existing methods for identifying such variants have poor predictive power. Here, we introduce a new computational method, called LINSIGHT, that substantially improves the prediction of noncoding nucleotide sites at which mutations are likely to have deleterious fitness con...

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Literature Corpus work: d23f661c-1081-5b9c-9f32-4a78a3978ce4
DOI: 10.1101/069682

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