Article

Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection

2021-12-22

Abstract excerpt

<h4>ABSTRACT</h4> HLA is a critical component of the viral antigen presentation pathway. We investigated the relationship between severity of SARS-CoV-2 disease and HLA type in 3,235 individuals with confirmed SARS-CoV-2 infection. We found only the DPB1 locus to be associated with the binary outcome of whether an individual developed any COVID-19 symptoms. The number of peptides predicted to bind to an HLA allele...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 32f619af-cd18-552f-980b-a2e2716b0e86
DOI: 10.1101/2021.12.22.21268062

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infectionDOI 10.1101/2021.12.22.21268062Read

Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection.Semantic proximity Read

Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature.Semantic proximity Read

The role of HLA genetic variants in COVID ‐19 susceptibility, severity, and mortality: A global reviewSemantic proximity Read

The association of human leucocyte antigen (HLA) alleles with COVID-19 severity: A systematic review and meta-analysis.Semantic proximity Read

Association between human leukocyte antigen alleles and COVID-19 disease severity.Semantic proximity Read

Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity.Semantic proximity Read

Association between HLA gene polymorphisms and mortality of COVID-19: An in silico analysis.Semantic proximity Read

Current HLA Investigations on SARS-CoV-2 and PerspectivesSemantic proximity Read

Identification of risk and protective human leukocyte antigens in COVID-19 using genotyping and structural modelingSemantic proximity Read

Bioinformatic HLA Studies in the Context of SARS-CoV-2 Pandemic and Review on Association of HLA Alleles with Preexisting Medical Conditions.Semantic proximity Read

HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19.Semantic proximity Read

Association of HLA gene polymorphism with susceptibility, severity, and mortality of COVID-19: A systematic review.Semantic proximity Read