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Article

Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity.

Frontiers in immunology - 1 Jan 2021

Schetelig Johannes, Heidenreich Falk, Baldauf Henning, Trost Sarah, Falk Bose, Hoßbach Christian, Real Ruben, Roers Axel, Lindemann Dirk, Dalpke Alexander, Kolditz Martin, de With Katja, Bornhäuser Martin, Bonifacio Ezio E, Rücker-Braun Elke, Lange Vinzenz, Markert Jan, Barth Ralf, Hofmann Jan A, Sauter Jürgen, Bernas Stefanie N, Schmidt Alexander H

Abstract excerpt

HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data from 6,919 infected individuals. HLA-A, -B, and -DRB1 allotypes grouped into HLA supertypes by functional or predicted structural similarities of the peptide-binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epitopes, T-Lymphocyte

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Source

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Identifiers

PMID: 34381451
DOI: 10.3389/fimmu.2021.698193
PMCID: PMC8350391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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