Article
HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19.
HLA - 1 Dec 2023
Castro-Santos Patricia, Rojas-Martinez Augusto, Riancho José A, Lapunzina Pablo, Flores Carlos, Carracedo Ángel, Díaz-Peña Roberto
Abstract excerpt
We analyzed the association between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from a total of 9373 COVID-19-positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID-19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA-B*14:02 and HLA-C*08:02 with a lower...
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