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Article

Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection.

HLA - 1 Jun 2022

Nguyen Austin, Yusufali Tasneem, Hollenbach Jill A, Nellore Abhinav, Thompson Reid F

Abstract excerpt

HLA is a critical component of the viral antigen presentation pathway. We investigated the relationship between the severity of SARS-CoV-2 disease and HLA type in 3235 individuals with confirmed SARS-CoV-2 infection. We found only the DPB1 locus to be associated with the binary outcome of whether an individual developed any COVID-19 symptoms. The number of peptides predicted to bind to an HLA allele had no...

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Identifiers

PMID: 35118818
DOI: 10.1111/tan.14574
PMCID: PMC10464832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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