Article

TGFβ signaling pathway is altered by HLA-B27 expression, resulting in pathogenic consequences relevant for spondyloarthritis.

2023-12-21

Abstract excerpt

<title>Abstract</title> <p>Background Association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years, but still remains unexplained. We recently showed that HLA-B27expressed in wing imaginal disc from HLA-B27/human-β2 microglobulin (hβ2m) transgenic <italic>Drosophila</italic> deregulated bone morphogenetic protein (BMP) pathway by interacting physically with type I BMP receptor (BMPR1) Saxophon...

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Literature Corpus work: 32bb359b-c48a-57e1-a499-0d233f3fcb05
DOI: 10.21203/rs.3.rs-3749796/v1

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