Article

Syncytins enable novel possibilities to transduce human or mouse primary B cells and to achieve well-tolerated <i>in vivo</i> gene transfer

2019-10-24

Abstract excerpt

Syncytins are cellular transmembrane glycoproteins with fusogenic and immunosuppressive properties that are encoded by endogenous retroviral envelope sequences in mammalian genomes. Based on their properties, syncytins may be useful to pseudotype lentiviral gene transfer vectors (LV) and to obtain well-tolerated in vivo gene delivery but their cellular targets are unknown in this context. We pseudotyped LV with h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 32853674-fbdb-5cfc-96b7-b61d4dff4b2e
DOI: 10.1101/816223

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Syncytins enable novel possibilities to transduce human or mouse primary B cells and to achieve well-tolerated <i>in vivo</i> gene transferDOI 10.1101/816223Read

Lentiviral Vector Pseudotypes: Precious Tools to Improve Gene Modification of Hematopoietic Cells for Research and Gene TherapySemantic proximity Read

The role of syncytins in human reproduction and reproductive organ cancersSemantic proximity Read

Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cellsSemantic proximity Read

Syncytia Formation Promotes Virus Resistance to Interferon and Neutralizing AntibodiesSemantic proximity Read

Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCsSemantic proximity Read

Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiencySemantic proximity Read

Heterologous Avian System for Quantitative Analysis of Syncytin-1 Interaction with ASCT2 ReceptorSemantic proximity Read

A Nontoxic Transduction Enhancer Enables Highly Efficient Lentiviral Transduction of Primary Murine T Cells and Hematopoietic Stem CellsSemantic proximity Read

Discovery and Validation of Alternatives to VSV-G for Pseudotyping of Lentiviral Vectors for In Vivo Delivery of Anti-Tumor TransgenesSemantic proximity Read

Enhanced lentiviral gene delivery to mammalian cells via paired cell surface and viral envelope engineeringSemantic proximity Read

C-Terminal truncations of syncytin-1 (ERVWE1 envelope) that increase its fusogenicity.Semantic proximity Read

Cell Fusion and Syncytium Formation in Betaherpesvirus InfectionSemantic proximity Read