Article

Tumour suppressor WT1 regulates the let-7- <i>Igf1r</i> axis in kidney mesenchyme

2019-10-30

Abstract excerpt

Wilms’ tumour 1 (WT1) is a transcription factor and a tumour suppressor, essential for the development and homeostasis of multiple tissues derived from the intermediate and lateral plate mesoderm. Germline WT1 mutations result in the eponymous paediatric kidney cancer, genitourinary anomalies and in some cases congenital diaphragmatic hernia One common feature in Wilms’ Tumours (WT), is upregulation of IGF2 throu...

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Literature Corpus work: 327e627a-6696-5571-91b9-eb670c6c0057
DOI: 10.1101/822973

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