Article

Why tyrosine kinase inhibitor resistance is common in advanced gastrointestinal stromal tumors

2013-07-09

Abstract excerpt

<h4>Background: </h4> Most patients with advanced gastrointestinal stromal tumors (GIST) develop drug resistance to tyrosine kinase inhibitors (TKIs) within two years of starting therapy, whereas most chronic myeloid leukemia (CML) patients in chronic phase still exhibit disease control after a decade on therapy. This article aims to explain this divergence in long term outcomes. <h4>Methods: </h4> and results: B...

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Literature Corpus work: 32748769-eafe-5549-9501-147a869ecc81
DOI: 10.12688/f1000research.2-152.v1

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