Article
Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review).
Oncology reports - 1 Jun 2009
Maleddu Alessandra, Pantaleo Maria A, Nannini Margherita, Di Battista Monica, Saponara Maristella, Lolli Cristian, Biasco Guido
Abstract excerpt
Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging aspect in medical oncology especially in the era of target therapies. The aim of this review is to...
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