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Article

Current Drug Resistance Mechanisms and Treatment Options in Gastrointestinal Stromal Tumors: Summary and Update.

Current treatment options in oncology - 1 Nov 2024

He Chunxiao, Wang Zilong, Yu Jiaying, Mao Shuang, Xiang Xi

Abstract excerpt

OPINION STATEMENT: Gastrointestinal stromal tumor (GIST) is characterized by well-defined oncogenes. Despite the significant improvement in treatment outcomes with adjuvant imatinib therapy for patients, drug resistance remains a major challenge for GIST therapy. This review focuses on the mechanisms contributing to drug resistance phenotype in GIST, such as primary imatinib-resistant mutants, secondary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39441520
DOI: 10.1007/s11864-024-01272-7
PMCID: PMC11541409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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