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Article

Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia

1 Jul 2023

Abstract excerpt

In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia (R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable remissions, which requires the persistence of CAR-T cells. In this study, we systematically analyzed CD19 CAR-T cells of 10 children with R/R B-ALL enrolled in the CARPALL trial via high-throughput single-cell gene expression and T...

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PMID: 37407840
DOI: 10.1038/s41591-023-02415-3

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