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Cathelicidin senses enteric pathogen <i>Salmonella typhimurium/</i> LPS for colonic chemokine generation: a new innate immune role for a host defense peptide

2018-08-10

Abstract excerpt

The mechanisms by which epithelia identify and respond to pathogens are manifold, nuanced and complex. Here, using human-colon derived HT29 epithelial cells, mouse and human primary colonoids, and cathelicidin null (Cramp) mice, we report a novel immunoregulatory role for the antimicrobial peptide, cathelicidin, that was found to recognize and synergise with Salmonella typhimurium or its derived virulence factor...

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Literature Corpus work
32222d19-faf4-510c-9d2a-27f8a49998b8
DOI
10.1101/389726
Open publication

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