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ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy

2023-10-22

Abstract excerpt

Chronic kidney disease (CKD) is often associated with protein-energy wasting (PEW), which is characterized by a reduction in muscle mass and strength. Although mitochondrial dysfunction and oxidative stress have been implicated to play a role in the pathogenesis of muscle wasting, the underlying mechanisms remain unclear. In this study, we used transcriptomics, metabolomics analyses and mouse gene manipulating app...

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Identifiers and source

Literature Corpus work
31d95b49-29ba-5d5c-8a7c-829925cabeac
DOI
10.1101/2023.10.22.563469
Open publication

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ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophyDOI 10.1101/2023.10.22.563469
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