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A Trojan horse biomimetic delivery system using mesenchymal stem cells for HIF-1α siRNA -loaded nanoparticles on RPE cells under hypoxia environment

2022-03-17

Abstract excerpt

AIM: To demonstrate the feasibility of mesenchymal stem cell (MSC)-mediated nano drug delivery, which was characterized by the “Trojan horse”-like transport of HIF-1α siRNA between MSCs and retinal pigment epithelial cells (RPE) under hypoxia environment. METHODS: Plasmid and lentivirus targeting the human HIF-1α gene were designed and constructed by Genechem company. HIF-1α siRNA was encapsulated into Poly (lacti...

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Literature Corpus work
31d758aa-4bd9-5375-a67a-a8dec7408134
DOI
10.21203/rs.3.rs-1385244/v1
Open publication

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A Trojan horse biomimetic delivery system using mesenchymal stem cells for HIF-1α siRNA -loaded nanoparticles on RPE cells under hypoxia environmentDOI 10.21203/rs.3.rs-1385244/v1
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