Article

Abacavir enhances the efficacy of Doxorubicin via inhibition of histone demethylase KDM5B in breast cancer

2025-04-03

Abstract excerpt

<title>Abstract</title> <p>KDM5B, a lysine-specific histone demethylase, is widely upregulated in breast cancer. The current study investigated the role of KDM5B in breast cancer and explored the repurposing potential of the antiviral drug abacavir (ABC). The cytotoxic effects and the effect of ABC sensitization on doxorubicin (DOX) efficacy were evaluated using 2-D and 3-D cell culture models. KDM5B expression w...

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Identifiers and source

Literature Corpus work: 31898c80-173a-506e-b2de-c1c585fbeade
DOI: 10.21203/rs.3.rs-6208718/v1

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