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Article

Role of Differentially Expressed Proteins in Acquired Resistance to Cdk4/6 Inhibitor in Breast Cancer

2021-05-27

Abstract excerpt

<title>Abstract</title> <p>CDK4/6 inhibitors (Abemaciclib, Ab and Palbociclib, Pb) stop the G1-phase in cell-cycle being used to cure advanced stage of breast cancer (BC). Acquired resistance is a major challenge in BC therapy. The molecular signature of the therapy resistance for Ab and Pb drugs in BC should be explored. Here, we developed Ab/Pb-resistant cell-models and explored the molecular changes. Drug’s re...

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Literature Corpus work
53e9ce98-33c8-562a-9232-761024dd5c61
DOI
10.21203/rs.3.rs-556331/v1
Open publication

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Role of Differentially Expressed Proteins in Acquired Resistance to Cdk4/6 Inhibitor in Breast CancerDOI 10.21203/rs.3.rs-556331/v1
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