Article
Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy
2016-07-19
Abstract excerpt
Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched for positive selection signals underlying coronary artery disease (CAD) in worldwide populations, using novel approaches to quantify relationships b...
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Identifiers and source
- Literature Corpus work
- 318803f5-a59f-561c-9fcd-1e5546504dac
- DOI
- 10.1101/064758