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Article

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy.

PLoS genetics - 1 Jun 2017

Byars Sean G, Huang Qin Qin, Gray Lesley-Ann, Bakshi Andrew, Ripatti Samuli, Abraham Gad, Stearns Stephen C, Inouye Michael

Abstract excerpt

Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched for positive selection signals underlying coronary artery disease (CAD) in worldwide populations, using novel approaches to quantify relationships...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28640878
DOI: 10.1371/journal.pgen.1006328
PMCID: PMC5480811

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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