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Article

Maternal obesity is associated with phenotypic alterations in fetal immune cells by single-cell mass cytometry.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Mar 2021

Enninga Elizabeth Ann L, Jang Jin Sung, Hur Benjamin, Johnson Erica L, Wick Myra J, Sung Jaeyun, Chakraborty Rana

Abstract excerpt

PROBLEM: Prenatal exposure to metabolic dysregulation arising from maternal obesity can have negative health consequences in post-natal life. To date, the specific effects of maternal obesity on fetal immunity at a cellular level have not been well characterized. METHOD OF STUDY: Using cord blood mononuclear cells (CBMCs) and cord plasma (n = 9/group) isolated from infants born to women with a high body mass...

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Identifiers

PMID: 33064324
DOI: 10.1111/aji.13358
PMCID: PMC8109213

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