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Article

Maternal high-fat diet and obesity compromise fetal hematopoiesis

18 Nov 2014

Abstract excerpt

OBJECTIVE: Recent evidence indicates that the adult hematopoietic system is susceptible to diet-induced lineage skewing. It is not known whether the developing hematopoietic system is subject to metabolic programming via in utero high-fat diet (HFD) exposure, an established mechanism of adult disease in several organ systems. We previously reported substantial losses in offspring liver size with prenatal HFD. As...

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PMID: 25685687
DOI: 10.1016/j.molmet.2014.11.001

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