Article
Frequency of BCR-ABL fusion transcripts in Iranian patients with chronic myeloid leukemia.
1 May 2008
Abstract excerpt
BACKGROUND: A specific chromosomal abnormality, the Philadelphia chromosome, is present in 90 - 95% of patients with chronic myeloid leukemia. The aberration results from a reciprocal translocation of chromosomes 9 and 22, creating a BCR-ABL fusion gene. There are two major forms of the BCR-ABL fusion gene, involving ABL exon 2, but including different exons of BCR gene. The transcript b2a2 or b3a2 codes for a...
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