Article

Strain level variation in <i>Proteus mirabilis</i> chondroitin sulfate degradation kinetics and regulation by urea

2026-03-24

Abstract excerpt

To establish infection, uropathogens must overcome several host defenses including the glycosaminoglycan (GAG) layer coating the apical surface of the bladder urothelium. GAGs are thought to protect against urinary tract infection (UTI) by serving as scaffolding sites for commensals, providing barrier function and preventing uropathogen adherence. However, the ability of uropathogens to degrade and utilize GAGs an...

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Literature Corpus work: 314efc9c-ba02-528e-bf17-48e409fc9fbc
DOI: 10.64898/2026.03.23.713754

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