Article
Contribution of three tRNA modification enzymes to Proteus mirabilis fitness and catheter-associated urinary tract infection.
Infection and immunity - 9 Jun 2026
Brix Vitus, Hunt Benjamin C, Learman Brian S, Brauer Aimee L, Armbruster Chelsie E
Abstract excerpt
RNA modifications play essential roles in cellular physiology by modulating RNA structure, stability, and translation efficiency. Among these, dihydrouridine is a conserved tRNA modification synthesized by the flavin-dependent enzymes DusA, DusB, and DusC, which introduce flexibility at defined uridine positions in the D-loop. While structural and biochemical studies in Escherichia coli have clarified...
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