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Article

Specific binding of the pathogenic prion isoform: development and characterization of a humanized single-chain variable antibody fragment.

PloS one - 20 Jan 2011

Skrlj Nives, Vranac Tanja, Popović Mara, Curin Šerbec Vladka, Dolinar Marko

Abstract excerpt

Murine monoclonal antibody V5B2 which specifically recognizes the pathogenic form of the prion protein represents a potentially valuable tool in diagnostics or therapy of prion diseases. As murine antibodies elicit immune response in human, only modified forms can be used for therapeutic applications. We humanized a single-chain V5B2 antibody using variable domain resurfacing approach guided by computer...

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Identifiers

PMID: 21283753
DOI: 10.1371/journal.pone.0015783
PMCID: PMC3024399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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