Article

Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains

2020-10-26

Abstract excerpt

Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues. In addition to collagen P4Hs and hypoxia-inducible factor P4Hs, a poorly characterized endoplasmic reticulum (ER)-localized transmembrane prolyl 4-hydroxylase (P4H-TM) is found in animals. P4H-TM variants are associated with the familiar neurological HIDEA syndrome. Here, the 3D structure of the soluble human P4H-T...

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Literature Corpus work: 313eac46-d048-5c55-a262-26a8b36355c2
DOI: 10.1101/2020.10.25.354423

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