Article
CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta.
Cell - 20 Oct 2006
Morello Roy, Bertin Terry K, Chen Yuqing, Hicks John, Tonachini Laura, Monticone Massimiliano, Castagnola Patrizio, Rauch Frank, Glorieux Francis H, Vranka Janice, Bächinger Hans Peter, Pace James M, Schwarze Ulrike, Byers Peter H, Weis MaryAnn, Fernandes Russell J, Eyre David R, Yao Zhenqiang, Boyce Brendan F, Lee Brendan
Abstract excerpt
Prolyl hydroxylation is a critical posttranslational modification that affects structure, function, and turnover of target proteins. Prolyl 3-hydroxylation occurs at only one position in the triple-helical domain of fibrillar collagen chains, and its biological significance is unknown. CRTAP shares homology with a family of putative prolyl 3-hydroxylases (P3Hs), but it does not contain their common dioxygenase...
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