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Article

Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.

PloS one - 1 Jan 2011

Riedel Travis J, Johnson Lynnette C, Knight John, Hantgan Roy R, Holmes Ross P, Lowther W Todd

Abstract excerpt

BACKGROUND: 4-hydroxy-2-oxoglutarate (HOG) aldolase is a unique enzyme in the hydroxyproline degradation pathway catalyzing the cleavage of HOG to pyruvate and glyoxylate. Mutations in this enzyme are believed to be associated with the excessive production of oxalate in primary hyperoxaluria type 3 (PH3), although no experimental data is available to support this hypothesis. Moreover, the identity, oligomeric...

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Identifiers

PMID: 21998747
DOI: 10.1371/journal.pone.0026021
PMCID: PMC3188589

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