Article

<i>HOXA</i> Amplification Defines a Genetically Distinct Subset of Angiosarcomas

2022-05-07

Abstract excerpt

Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of HOXA cluster genes in 33% of patients. HOXA genes are master regulators of embryonic vascular development and adult neovascularization, which provides a molecular rationale to suspect that amplified HOXA gene...

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Literature Corpus work: 30ce8123-225b-57fc-84d2-06323365315a
DOI: 10.1101/2022.05.06.22274708

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