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Article

Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations.

The American journal of surgical pathology - 1 May 2016

Huang Shih-Chiang, Zhang Lei, Sung Yun-Shao, Chen Chun-Liang, Kao Yu-Chien, Agaram Narasimhan P, Singer Samuel, Tap William D, D'Angelo Sandra, Antonescu Cristina R

Abstract excerpt

Angiosarcoma (AS) is a rare sarcoma subtype showing considerable clinicopathologic and genetic heterogeneity. Most radiation-induced AS show MYC gene amplifications, with a subset of cases harboring KDR, PTPRB, and PLCG1 mutations. Despite recent advances, the genetic abnormalities of most primary AS remain undefined. Whole-transcriptome sequencing was initiated in 2 index cases of primary soft tissue AS with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26735859
DOI: 10.1097/PAS.0000000000000582
PMCID: PMC4833528

Genes

CIC
MYC
KDR
PLCG1
FLT4
LEUTX
PTPRB

Provenance

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