Article

A general and extensible algorithmic framework to biological sequence alignment across scales and applications

2026-01-29

Abstract excerpt

Sequence alignment underpins nearly every facet of modern genomics, from genetic testing and cancer profiling to functional genome annotation. Yet, despite decades of algorithmic innovation, most existing aligners remain narrowly optimized for specific tasks, fragmenting analytical workflows and limiting reproducibility. Here we introduce the Versatile Alignment Toolkit (VAT), a unified algorithmic framework that...

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Literature Corpus work: 30878652-65e5-5480-a6ce-16aa937f07a6
DOI: 10.64898/2026.01.28.702355

Open publication

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