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Article

Fast read alignment with incorporation of known genomic variants.

BMC medical informatics and decision making - 19 Dec 2019

Guo Hongzhe, Liu Bo, Guan Dengfeng, Fu Yilei, Wang Yadong

Abstract excerpt

BACKGROUND: Many genetic variants have been reported from sequencing projects due to decreasing experimental costs. Compared to the current typical paradigm, read mapping incorporating existing variants can improve the performance of subsequent analysis. This method is supposed to map sequencing reads efficiently to a graphical index with a reference genome and known variation to increase alignment quality and...

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Identifiers

PMID: 31856811
DOI: 10.1186/s12911-019-0960-3
PMCID: PMC6921400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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