Article

Hidden origami in <i>Trypanosoma cruzi</i> nuclei highlights its nonrandom 3D genomic organization

2024-07-05

Abstract excerpt

The protozoan Trypanosoma cruzi , the causative agent of Chagas disease, exhibits polycistronic transcription and unidimensional genome compartmentalization of core (conserved) and disruptive (virulence factors from multigenic families) genes. Approximately 50% of its genome is repetitive, mainly virulence factor genes. Genomic sequences, including repeats, motifs of architectural proteins, and noncoding RNA lo...

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Literature Corpus work: 307b5d9c-4156-5eee-8421-5b1aae4ca09a
DOI: 10.1101/2024.07.01.601582

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