Article

First Genome-Wide Centromere Map of <i>Trypanosoma cruzi</i> Reveals Linear and 3D Compartment Boundaries and Spatial Clustering

2025-09-29

Abstract excerpt

<h4>Background: </h4> Trypanosoma cruzi , the etiological agent of Chagas disease, possesses a highly repetitive genome that has historically hindered high-quality assembly and structural characterization. Despite significant advances in assembling T. cruzi genomes, major gaps remain. Among these, the complete repertoire of centromeric sequences has remained elusive, representing a critical missing piece in our u...

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Literature Corpus work: 1641e542-7f83-59e4-bc59-aeef4ff3964e
DOI: 10.1101/2025.09.26.678825

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