Article

Ensilication preserves high-molecular weight native DNA for clinical long-read sequencing

2025-11-03

Abstract excerpt

Long-read DNA sequencing detects genetic variants and epigenetic modifications simultaneously, but optimal preservation of molecular length and base modifications typically requires cold-chain infrastructure. This infrastructure dependence restricts genomics to well-resourced laboratories and limits field research. We show that ensilication, the encapsulation of DNA within silica matrices, preserves DNA integrity...

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Literature Corpus work: 306d2c3d-a5fb-5a6b-a23a-600bb4408790
DOI: 10.1101/2025.10.26.25338579

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