Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modification of COL1A1 in Autologous Adipose Tissue-Derived Progenitor Cells Rescues the Bone Phenotype in a Mouse Model of Osteogenesis Imperfecta.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2021

Liu Yi, Wang Zihan, Ju Mingyan, Zhao Yuxia, Jing Yaqing, Li Jiaci, Shao Chenyi, Fu Ting, Lv Zhe, Li Guang

Abstract excerpt

Osteogenesis imperfecta (OI) is a congenital genetic disorder mainly manifested as bone fragility and recurrent fracture. Mutation of COL1A1/COL1A2 genes encoding the type I collagen are most responsible for the clinical patients. Allogenic mesenchymal stem cells (MSCs) provide the potential to treat OI through differentiation into osteoblasts. Autologous defective MSCs have not been utilized in OI treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Collagen Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type I, alpha 1 Chain

Share to Mesenchymal Stem Cells

Share to Osteogenesis

Share to Osteogenesis Imperfecta

Share to Phenotype

Source

Identifiers

PMID: 33950576
DOI: 10.1002/jbmr.4326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modification of COL1A1 in Autologous Adipose Tissue-Derived Progenitor Cells Rescues the Bone Phenotype in a Mouse Model of Osteogenesis Imperfecta.PMID 33950576Read ↗

Restoration of Osteogenesis by CRISPR/Cas9 Genome Editing of the Mutated COL1A1 Gene in Osteogenesis ImperfectaSemantic proximity Read ↗

Pleotropic effects of a recessive C <i>OL1α2</i> mutation occurring in a mouse model of severe osteogenesis imperfectaSemantic proximity Read ↗

AAV-based gene editing of type 1 collagen mutation to treat osteogenesis imperfectaSemantic proximity Read ↗

An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug ScreeningSemantic proximity Read ↗

Identification of a family with van der Hoeve's syndrome harboring a novel COL1A1 mutation and generation of patient-derived iPSC lines and CRISPR/Cas9-corrected isogenic iPSCs.Semantic proximity Read ↗

An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug ScreeningSemantic proximity Read ↗

Normal Collagen and Bone Production by Gene-targeted Human Osteogenesis Imperfecta iPSCsSemantic proximity Read ↗

Gene targeting in stem cells from individuals with osteogenesis imperfecta.Semantic proximity Read ↗

Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease.Semantic proximity Read ↗

Characterization of a Novel Col1a1G643S/+ Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations.Semantic proximity Read ↗

Genetic causes and mechanisms of Osteogenesis Imperfecta.Semantic proximity Read ↗

Osteogenesis imperfecta.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.