New Genes in Bone Development: What's New in Osteogenesis Imperfecta

Abstract excerpt

Osteogenesis imperfecta (OI) is a heritable bone dysplasia characterized by bone fragility and deformity and growth deficiency. Most cases of OI (classical types) have autosomal dominant inheritance and are caused by mutations in the type I collagen genes. During the past several years, a number of noncollagenous genes whose protein products interact with collagen have been identified as the cause(s) of rare...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone and Dental Protein Studies
• Share to Connective tissue disorders research
• Share to Protease and Inhibitor Mechanisms