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Article

Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance

22 Nov 2019

Abstract excerpt

Most cancers are resistant to anti-PD-1/PD-L1 and chemotherapy. Herein we identify PDLIM2 as a tumor suppressor particularly important for lung cancer therapeutic responses. While PDLIM2 is epigenetically repressed in human lung cancer, associating with therapeutic resistance and poor prognosis, its global or lung epithelial-specific deletion in mice causes increased lung cancer development, chemoresistance, and...

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PMID: 31757943
DOI: 10.1038/s41467-019-13331-x

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