Article

Primary macrophages exhibit a modest inflammatory response early in SARS-CoV-2 infection

2022-02-04

Abstract excerpt

Involvement of macrophages in the SARS-CoV-2-associated cytokine storm, the excessive secretion of inflammatory/anti-viral factors leading to the acute respiratory distress syndrome (ARDS) in COVID-19 patients, is unclear. In this study, we sought to characterize the interplay between the virus and primary human monocyte-derived macrophages (MDM). MDM were stimulated with recombinant IFN-α and/or infected with eit...

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Literature Corpus work: 2face74a-0a9b-5c01-8099-ecc00f625705
DOI: 10.1101/2022.02.02.478897

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