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Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages

23 Mar 2012

Abstract excerpt

Systemic infections with HPAIVs, such as H5N1, are characterized by cytokine burst and sepsis. We investigated the role of human monocyte-derived macrophages in these events after infection with different influenza virus strains. Macrophages were infected with low pathogenic H1N1 (PR8) or high pathogenic H7N7 (FPV) and H5N1 (KAN-1) subtypes. Macrophages were found to be nonpermissive for influenza virus...

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PMID: 22442495
DOI: 10.1189/jlb.0911479

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