Article
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.
Nature reviews. Cancer - 1 Jul 2014
Holderfield Matthew, Deuker Marian M, McCormick Frank, McMahon Martin
Abstract excerpt
The identification of mutationally activated BRAF in many cancers altered our conception of the part played by the RAF family of protein kinases in oncogenesis. In this Review, we describe the development of BRAF inhibitors and the results that have emerged from their analysis in both the laboratory and the clinic. We discuss the spectrum of RAF mutations in human cancer and the complex interplay between the...
Topics
- Animals
- Drug Resistance, Neoplasm
- Humans
- Melanoma
- Mutation
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins B-raf
- Skin Neoplasms