Targeting RAS/RAF/MEK/ERK signaling in metastatic melanoma

doi:10.1002/iub.1193

Article

Targeting RAS/RAF/MEK/ERK signaling in metastatic melanoma

29 Jul 2013

Abstract excerpt

The RAS/RAF/MEK/ERK pathway has been reported to be activated in over 80% of all cutaneous melanomas, making it the focus of many scientific studies in the melanoma field. Discoveries of mutations and aberrant expression of components in this cascade, in particular, BRAF and NRAS render a deeper understanding of the mechanisms responsible for oncogenesis and provide new therapeutic strategies for this deadly...

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